Ligand-competent fractalkine receptor is expressed on exosomes
نویسندگان
چکیده
منابع مشابه
Fractalkine receptor/ligand genetic variants and carotid intima-media thickness.
BACKGROUND AND PURPOSE The fractalkine ligand/receptor (CX3CL1/CX3CR1) complex is important in inflammatory responses and has been associated with vascular disease. We determined whether genetic variants in CX3CL1 and CX3CR1 are associated with carotid atherosclerosis in 2 large European populations. METHODS 18 polymorphisms in CX3CL1 and CX3CR1 were genotyped in 2763 German community individ...
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BACKGROUND The goal of this study was to determine a predominant cell type expressing fractalkine receptor (CX3CR1) in mature ovarian teratomas and to establish functional significance of its expression in cell differentiation. METHODS Specimens of ovarian teratoma and human fetal tissues were analyzed by immunohistochemistry for CX3CR1expression. Ovarian teratocarcinoma cell line PA-1 was us...
متن کاملCalcitonin receptor-like receptor is expressed on gastrointestinal immune cells.
BACKGROUND/AIMS Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact. We aimed to determine whether gut immune cells are targets for calcitonin gene-related peptide (CGRP), which has potent immune regulatory properties. METHODS Using density gradient centrifugation, rat lamina propria mononuclear cells (LP-MNC...
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Fractalkine (CX3CL1, FKN) is expressed in the inflamed vascular wall and absence of FKN reduces atherogenesis. Whether FKN is expressed throughout all stages of atherosclerotic disease and whether it directly contributes to monocyte recruitment to atherosclerotic lesions is not known. We collected human atherosclerotic plaque material and blood samples from patients with carotid artery disease ...
متن کاملCD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes
Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investiga...
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ژورنال
عنوان ژورنال: Biochemistry and Biophysics Reports
سال: 2021
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2021.100932